evaluating the level of serum il-23 in brucellosis infection by elisa and investigating its relationship in cases with failure to respond to treatment

Brucella is belonging to the small immobile gram-negative spore-lacking cocco-bacilli bacteria family that grows in an aerobic environment, it is known as a zoonosis infection named brucellosis. this study was designed to investigate serum values of il-23 in patient with brucellosis and investigate its relationship with cases with failure to respond to conventional medical therapy. a total of 372 individuals were divided into 2 groups (n=186) as follows: group a comprising 186 infected participants with brucella (7-80 years-old), these people had not received antibiotics for at least 6 months ago. group b including the healthy participants. all the participants in both groups were in the same age range. 5 ml blood samples were obtained from the participants intravenously (without anticoagulation substance). the serum level of il-23 was investigated by elisa diagnostic kit. the recorded data showed that the levels of il-23 in the serum samples obtained from group a (143.64 pg/ml) significantly (p<0.001) increased compared with this value in group b (23.14 pg/ml). based on the recorded data in the forms completed by all the participants at the day 0 of the experiment, 44 out of 186 individuals in group a, had experienced brucellosis attack 2-3 times in spite of receiving medical prescriptions. a hypothesis about the possible immune system disorders in these participants lead us to did the re-sampling following drug administration. results illustrated failure to respond to conventional medical therapy in patients with low level of serum il-23.