plasma paraoxonase, sphingosine1phosphate, total sialic acid, and heat shock protein27 in the liver of the sheep naturally infected with cysticercus tenuicollis: evidence on pathological changes

The present study aimed to investigate whether sphingosine 1 phosphate (s1p), paraoxonase (pon), total sialic acid (tsa), and heat shock protein-27 (hsp27) are altered in the sheep during infection of the liver with cysticercus tenuicollis. this study was conducted on40 healthy sheep and40 sheep with cysticercus tenuicollis infection. the infected and non-infected animals were selected based on the observation of severe cysticercus tenuicollis infection in the liver and absence of any hepatic cysts, respectively. all parameters were measured in serum and plasma. the results revealed a significant decrease (p<0.01) in pon, tsa, and albumin (alb) in the infected group, compared with those in the healthy one. furthermore, the infected sheep had a significant increase (p<0.01) in s1p, hsp-27, malondialdehyde (mda), total bilirubin, and unconjugated bilirubin as compared with those in their non-infected counterparts. moreover, no significant change was observed in total plasma protein level in the infected animals in comparison to that in the healthy ones. the low levels of tsa and alb revealed liver damage in the infected sheep. moreover, the pon reduction might have resulted from hepatic steatosis and mda enhancement. meanwhile, s1p elevation could be attributed to the activation of platelets. in addition, hsp-27 increase was ascribed to the disease-induced stress conditions.