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Solvent-free synthesis of 3-benzylpyrano[3,2-c]pyran/chromene-2,5-diones via tandem reaction of 4-hydroxy-6-methyl-pyran-2-one and 4-hydroxycoumarin with Baylis-Hillman adduct acetates
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نویسنده
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Matloubi Moghaddam F. ,Koushki Foroushani B. ,Lotfi Kalahroodi E.
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منبع
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scientia iranica - 2014 - دوره : 21 - شماره : 3-C1 - صفحه:735 -741
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چکیده
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4-hydroxycoumarin 2a and 4-hydroxy-6-methyl-pyran-2-one 2b were applied in a one-pot reaction with baylis-hillman adduct acetates 1 to form novel 3-benzylpyrano [3, 2-c] pyran-2, 5-diones 3 in high yields (70-85%). the synthesized framework is available in many biologically active moieties. the reaction was carried out under different conditions to achieve optimum conditions. the results indicated that et3n, as a base under solvent-free conditions, was optimum. the reaction procedure and purification method are mild and straightforward.
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کلیدواژه
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Baylis-Hilman adduct acetate; 4-hydroxycoumarin; Annulated 2-pyrone; Solvent-free conditions
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آدرس
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sharif university of technology, Laboratory of Organic Synthesis and Natural Products, Department of Chemistry, ایران, sharif university of technology, Laboratory of Organic Synthesis and Natural Products, Department of Chemistry, ایران, sharif university of technology, Laboratory of Organic Synthesis and Natural Products, Department of Chemistry, ایران
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Authors
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