Synthesis and characterization of calcium alginate nanoparticles, sodium homopolymannuronate salt and its calcium nanoparticles

Calcium alginate nanoparticles as excellent carriers in drug delivery systems were synthesizedby controlled gellification method and characterized with fourier transform infrared spectroscopy(ftir). to compare mean particle size and distribution of calcium alginate nanoparticles withhomopolymannuronate ones, later nanoparticles were prepared through the same conditions. sodiumhomopolymannuronate is one of the ingredients of alginate polymer which was synthesized and purifiedby partial acid hydrolysis of sodium alginate and characterized with ftir spectroscopy. results showedsignificant improvement of size and distribution of calcium alginate nanoparticles with decrease of sodiumalginate and increase of calcium cation concentrations, respectively. in addition, lower mean particle sizeand better distribution of calcium homopolymannuronate nanoparticles was observed in comparison withcalcium alginate ones. this result may refer to the ionic interaction of calcium crosslinker ions with regularhomopolymeric chains of homopolymannuronate compared to no regular chains of alginate polymer.