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Calcium oxide nanoparticles catalyzed one-step multicomponent synthesis of highly substituted pyridines in aqueous ethanol media
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نویسنده
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Safaei-Ghomi J. ,Ghasemzadeh M.A. ,Mehrabi M.
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منبع
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scientia iranica - 2013 - دوره : 20 - شماره : 3 - صفحه:549 -554
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چکیده
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An efficient one-pot three-component condensation of aldehydes, thiols and malononitrilehas been developed in the presence of calcium oxide nanoparticles. highly substituted pyridines asprivileged medicinal scaffolds have been efficiently prepared via carboncarbon and carbonheteroatombond formation. this method provides a novel and improved approach for the synthesis of 2-amino-4-aryl-3,5-dicyano-6-sulfanylpyridines in terms of excellent yields, short reaction times, reusability and littlecatalyst loading.
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کلیدواژه
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Multicomponent reactions; ,Nanoparticles; ,Calcium oxide; ,Poly functionalized pyridines; ,Heterogeneous catalyst; ,One-pot.
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آدرس
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university of kashan, he is Head of the International Science Cooperation Office, ایران, university of kashan, Ph D degrees, ایران, university of kashan, Ph D degree student , ایران
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Authors
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