Solubilities of acetaminophen in supercritical carbon dioxide with and without menthol cosolvent: Measurement and correlation

The solubility of acetaminophen in supercritical-carbon dioxide (sc-co2) with and withoutmenthol as a cosolvent was measured at various temperatures (313, 328 and 343) k, and within pressuresranging from (10 to 25) mpa. it should be stated that the cosolvent, menthol, has chiral isomers withdifferent melting points. therefore, the effects of both menthol (i) with a lower melting point and menthol(ii) with a higher melting point, as cosolvents on the solubility of acetaminophen in sc-co2, were studied.the experimental data collected in this work were obtained using a static flow apparatus. the experimentswere replicated at least three times and the data reported are the average of the replicas. finally, thedata reduction for the solubility of acetaminophen in sc-co2 in the presence and in the absence ofmenthol (i) and menthol (ii), were correlated, using the semi-empirical equations proposed by chrastiland mendez-santiago & teja. the results obtained from these equations were in good agreement with theexperimental data.