An immersed boundary-lattice Boltzmann model for simulation of malaria-infected red blood cell in micro-channel

The mechanical properties of red blood cells (rbcs) are influenced by invasion and occupationof plasmodium falciparum (pf ). the corresponding variation results from the stiffening of rbcs and theirability to adhere to endothelial cells. in this study, the transient deformation of plasmodium falciparum-parasitized red blood cell (pf -rbc) has been studied numerically. the cell is modeled as deformableliquid capsule enclosed by neo-hookean elastic membrane. the effect of shear elasticity is included, butbending stiffness is neglected. the numerical model is based on the immersed boundary-lattice boltzmannmethod (ib-lbm). the lbm is used to simulate fixed grid while the ibm is utilized to incorporate thefluid-membrane interaction in a lagrangian manner by a set of moving grids for membrane. the resultsinvestigate the significance of elastic shear modulus and initial shape on hematocrit ratio and deformationof pf -rbc at different stages. the pf -rbc at trophozoite and schizont stages obtain the lower hematocritratio, as they become near-circular. the results are in good agreement with experiments and previous