an efficient synthesis of pyrimido[4,5-b]quinoline and indenopyrido[2,3-d]pyrimidine derivatives in the presence of fe3o4@nano-cellulose/sb (v) as a bio-based magnetic nano-catalyst

In this study, an eco-friendly approach has been introduced for the synthesis of pyrimido[4,5-b]quinolones and indenopyrido[2,3-d]pyrimidines. this synthesis was done via a three component coupling of 6-amino-2-(methylthio)pyrimidin-4(3h)-one, 1,3-indanedione/dimedone and aromatic aldehydes using fe3o4@nano-cellulose/sb(v) as catalyst under solvent-free condition at 70 °c by electrical mortar-heater. the catalyst was separated from the reaction mixture by an external magnet and reused for subsequent reactions. the present procedure offers many advantages such as high yield, easy work-up, simple isolation of catalyst by external magnet and high reusability of the it. the structure of the obtained pyrimido[4,5-b]quinolones and indenopyrido[2,3-d]pyrimidines products were studied by ft-ir, 1h-nmr and 13c-nmr spectroscopic data.