Poincare section-based biomarkers of hemispheric asymmetry applied to autism spectrum disorder

Asymmetry and symmetry coexist in natural and human processes, and the interaction of asymmetric action (recursion) and symmetric opposition (sinusoidal waves) is instrumental in generating creative features. autism spectrum disorder (asd) is a disorder in which asymmetry and functionality of brain hemispheres are affected. in this study, difference in brain asymmetry in asd and normal children and the effect of voice on asymmetry are being investigated. due to abnormal cortical voice processing in asd, data recording is done in two situations: animation with audio (v-a) for 5 minutes and watching the animation with muted audio band (vwa). two indexes divergence (d) and number of poincare section points further from threshold (hd) as new biomarkers are being extracted. hemispheric asymmetry in asd children does not follow norm patterns, and h and hd indexes confirm a disorder in hemisphere's functionality in all statistical tests which can be globally unveiled with poincare section and extracted information. two remarkable features of the presented method are: data recording protocol specialized for asd children and new practical time-series analysis for detecting episodic patterns (complexes) as hallmark of asd dynamic and arrangement as an empirical measure of nonrandom complexity. the presented method could detect these complexes.