The Moderating Role of Personality Dimensions in the Relationship between Brain- Behavioral Systems and Multiple Sclerosis Severity

Multiple sclerosis (ms) is one of the neurological disorders that occur along with the degeneration of the myelin sheath. the aim of the present study was to investigate the moderating role of personality dimensions in the relationship between brain-behavioral systems and multiple sclerosis severity in individuals suffering from ms. this research was a correlational study in which 162 patients with ms were selected as statistical samples by the purposive sampling method in the city of shiraz. data were analyzed by pearson’s correlation coefficient and moderated regression. the findings revealed that brain-behavioral systems significantly predict ms severity (p <.01 and fchange= 5.66) and only the neuroticism dimension as the moderator significantly increased the determined variance on ms severity (p<.01, β=.77, and fchange= 54.22). therefore, neuroticism was able to moderate these relationships and increase their amounts. the obtained results confirmed the moderating role of neuroticism in the relationship between reinforcement sensitivity and the severity of the extent of disability in ms.