Differences between several atherogenic parameters in patients with Controlled and Uncontrolled Type 2 Diabetes Mellitus

Aim to assess the differences between atherogenic index of plasma (aip), ratio of oxidized-low density lipoprotein (ox- ldl)/high density lipoprotein (hdl) and ratio of lipoprotein-associated phospholipase a2 (lp-pla2)/hdl in predicting the risk of coronary heart disease (chd) in patients with controlled and uncontrolled type 2 diabetes mellitus (t2dm). methods the study was done observationally with cross sectional design. a total of 80 patients, consisted of 40 controlled and 40 uncontrolled t2dm. the serum triglyceride (tg), hdl-c, ox-ldl, lp-pla2 were examined in their relationship with t2dm risk. aip is a ratio calculated as log (tg/hdl-c). results aip and ratio of ox-ldl/hdl were significantly higher in uncontrolled than controlled t2dm (0.72 + 0.13 vs 0.47 ± 0.22 , p < 0.001) and (1738.8 ± 625.5 vs 1418 ± 535.3, p = 0.02), but no significant difference was found in ratio of lp-pla2/hdl (5.09 ± 2.17 vs 5.95 ± 3.11, p = 0.16). conclusion aip and ratio of ox-ldl/hdl value were significantly higher in uncontrolled than in controlled t2dm. these parameters may be beneficial in predicting the risk of atherosclerosis in diabetic patients. (med j indones 2010; 19:103-8)