The Relationship Between Retinol/Retinol Binding Protein 4 ratio, resistin and inflammation in non diabetic obese Indonesian men

Aim to verify the correlation between retinol/rbp4 ratio, and resistin with inflammation (represented by hscrp) in non-diabetic obese indonesian men methods this was a cross sectional study using 125 subjects. measured parameters were retinol, rbp4, resistin, and hscrp. correlation between retinol, rbp4, resistin, hscrp and retinol/rbp4 ratio was calculated. cut off point of hscrp were classiied as follows: <1 mg/l for low risk of inflammation, 1-3 mg/l for moderate risk, and 3-10 mg/l for high risk (according to cvd risk). the retinol/rbp4 ratio was dichotomized into high (>0.9) and low ratio (≤0.9). the cross tabulation test was performed to predict the inflammation trends described by retinol/rbp4 ratio and resistin. results retinol was found strongly correlated with rbp4 and resistin (r=0.53; p<0.01). a positive but not significant correlation was found between resistin and retinol/rbp4 ratio with hscrp. in high ratio group, 17.6% subjects were found with low risk inflammation, 26.4% with moderate risk, and 20.8% with high risk, in low ratio group, 8% subjects were low risk inflammation, 20% moderate risk, and 7.2% high risk. combination between ratio and resistin showed that in “high ratio and low resistin” group, 12% subjects have low risk of inflammation and 8% have high risk. meanwhile in “low ratio and high resistin” group, 3.2% subjects were found having low risk and 13.6% high risk of inflammation. conclusions combination between retinol/rbp4 ratio and resistin showed better description about the inflammation risk in non-diabetic obese subjects compare to the ratio itself. (med j indones 2010; 19:57-63)