Therapeutic effects of obesity surgery on glucose control in patients with type 2 diabetes

Background: obesity is considered as an independent risk factor for type 2 diabetes (t2d) and other metabolic diseases. obesity accounts for about 55% of diabetes. this study aimed to investigate the therapeutic effects of obesity surgery on glucose, hba1c, insulin and c-peptide serum levels in the patients with t2d. methods and materials: this prospective cohort study carried out on 25 patients aged between 18 -70 years who had with t2d and body mass index above 40 kg /m^2. fasting blood sugar (fbs) level, hba1c and two-hour postprandial (2hpp), insulin level, and cpeptide were measured in all patients before surgery and the patients were fully evaluated for the presence of diabetes complications. the patients underwent roux-en-y gastric bypass (rygb), mini-gastric bypass, and sleeve gastrectomy, and were re-evaluated 24 hours, one week, two month, and six months after surgery. results: twenty-five people underwent (sleeve gastrectomy for 12 cases, rygb for 7 cases and mini-bypass surgery for 6 cases). twenty cases (80.0%) were women and five cases (20.0%) were men. the mean age of the patients was 46.16 ± 10.97 years (25-67 years). the mean fasting blood sugar, 2hpp, hba1c, insulin, and c-peptide in general and in all three groups showed a significant decrease. conclusion: the findings of the study showed that all three surgical procedures were effective in improving t2d by six months after surgery.