The Role of Aerobic Exercise in the Gene Expression of Metallo Proteinase-2 and Angiostatin in Diabetic Rats' Heart Tissue

Background: the major effects of regular exercise on diabetes mellitus are glycemic status improvement and amelioration of cardiovascular dysfunctions. this research examines whether moderate-intensity aerobic exercise can change the gene expression of metalloproteinase-2 and angiostatin in diabetic rats’ heart tissue.materials & methods: in this experimental study, thirty wistar rats were categorized into the 3 groups diabetic exercise (n = 10), sedentary diabetes (n = 10), and healthy control (n = 10). to this end, moderate-intensity aerobic exercise was performed on a treadmill for 6 weeks. real-time pcr was used to measure metalloproteinase-2 and angiostatin gene expression. serum cortisol concentrations were measured using an elisa kit. the one-way anova and tukey’s post-hoc test was used to check significant differences among the groups.results: a significant decrease in metalloproteinase-2 gene expression (p < 0/001) as well as a significant increase in angiostatin gene expression (p < 0/001) and serum cortisol concentrations (p < 0/001) were observed in the sedentary diabetes group compared to the healthy control group. besides, a significant increase in metalloproteinase-2 gene expression (p < 0/001) as well as a significant decrease in angiostatin gene expression (p < 0/001) and serum cortisol concentrations (p < 0/001) were observed 6 weeks after the experiment in the diabetic exercise group compared to the sedentary diabetes group.conclusions: aerobic exercise improved metalloproteinase-2 and angiostatin gene expression in diabetic rats’ heart tissue. this finding on diabetic cardiac angiogenesis factors confirms the effect  of aerobic exercise.