the role and relationship of different bacteria in alzheimer's disease: effects; pathogenesis; complication

Background: the alzheimer's association restated the necessity of the brain gut axis within the context of studying the disease. with its broad-spectrum impact cutting across mnemonics, degeneration of cortex, and neurology, alzheimer's disease is known as a neurodegenerative disease. rising gudiance implicate ad as a progressive disease of the gut microbe dysbiosis with the gut ecosystem destruction resulting in the cascade of neuroinconsistency, accumulation of amyloid-β, compromise of blood brain barrier, and the impairment. metabolic aberration along with the inflammation caused by microbes such as chlamydia pneumoniae, helicobacter pylori and porphyromonas gingivalis have advanced the degeneration of the alzhemers patient.  the cyclic attack set forth by the bacterials in the brain together with the systemic cytokine secretion creates an inflammation and neurodegeneration enhancing loop which cannot be broken. such potential microb target therapies which aim not on the total elimination of the disease but on its on-going replacement are being later on presented within this review alongside with detailed explanation of the above mechanism. conclusion: alzheimer's disease relates to gut-brain axis; gut issues can cause inflammation and cognitive problems. certain bacteria may worsen ad. microbiome therapies could help; future research should target key microbial strains and conduct clinical trials for treatments