bacteriological profile of urinary tract infection in patients with nephrolithiasis and their antibiotic susceptibility profile attending a tertiary care hospital in north india

Background: nephrolithiasis is a common urological condition often associated with urinary tract infections (utis). identifying the bacteriological profile and antibiotic resistance patterns in such patients is essential for effective management and prevention of recurrence. to determine the bacteriological profile of urine in patients with nephrolithiasis and assess the antibiotic susceptibility patterns of the isolated organisms.methods: this cross-sectional observational study included 200 patients with nephrolithiasis at a tertiary care hospital. midstream urine samples were collected aseptically and cultured using standard microbiological techniques. isolated organisms were identified, and antibiotic susceptibility testing was performed using the kirby-bauer disc diffusion method in accordance with clsi guidelines. demographic data and other characteristics were also documented.results: out of 200 patients, 136 (68%) showed significant bacteriuria. escherichia coli was the most common isolate (44.1%), followed by enterococcus spp. (23.5%) and pseudomonas spp. (15.4%). e. coli showed high sensitivity to nitrofurantoin (96%) and amikacin (90%) but low sensitivity to ciprofloxacin (23%). enterococcus spp. exhibited good sensitivity to vancomycin (95%) and linezolid (93%) but high resistance to fluoroquinolones. pseudomonas spp. demonstrated high susceptibility to imipenem (89%) and piperacillin-tazobactam (80%).conclusion: urinary tract infections are common among patients with nephrolithiasis, with e. coli being the predominant pathogen. increasing resistance to commonly used antibiotics underscores the need for routine urine culture and sensitivity testing. culture-based therapy and antibiotic stewardship are vital to improving outcomes in these patients.