Prognostic and Demographic Characteristics of Acute Myelogenous Leukemia Patients: a Five- Year Study in Mashhad, Iran

Background: acute myeloid leukemia (aml) is a disease in elderly patients, with a mean age of diagnosis of 70 years. we evaluated the clinicopathological features and experimental variables in aml patients in northeastern iran as well as the correlation between survival and fab subgroups of aml. methods: from 2009 to 2014, 98 patients with aml were recruited in a retrospective study. most of the patients only received the chemotherapy regimen of “7+3” and none of the patients underwent radiotherapy. also, one-third of the patients underwent bone marrow transplantation. the mean follow-up period was 40 months and during this time, 58 deaths were found. results: the mean age of the patients at diagnosis was 40.6 ± 15.4 years (range, 17-77 years) and 40 patients (40.4%) were male. aml-m5 and m3 were the most frequent subgroups in patients with 29.5% and 26.1% frequencies, respectively. twenty patients (20.4%) had lymphadenopathy. weakness and lethargy were the most common complaints. the 5-year survival rate was 39.6% and mean survival was 27.3 months. prevalence of females was higher in aml-m5 and m3 compared to other subgroups. conclusions: the mean age in iran is lower than many countries; also, the frequency of females was higher in our study compared to many previous studies. overall survival of our patients was higher than other studies which can be due to the difference in types of treatment. the prevalence of aml-m5 in our study was higher than other studies.