Long Stress-induced Non-coding Transcript 5 rs2935641 Polymorphism and the risk of Bladder Cancer in Patients from Fars Province

Background: bladder cancer is one of the most common cancers in the world with a considerably higher frequency among men than women. in case of early diagnosis, it is possible to treat the disease; therefore, it is essential to identify useful markers. lsinct5 (long stress-induced non-coding transcript 5) is a stress-regulated lncrna involved in response to oxidative stress, also in cell proliferation and cancer development, especially in the presence of tobacco carcinogens. in this study, we aimed to evaluate the influence of lsinct5 gene polymorphism with the susceptibility of bladder cancer among a group of patients from the south of iran. methods: one hundred patients with bladder cancer and 100 healthy participants as the control group were investigated in this case-control study. genotyping of the rs2935641 polymorphism was carried out using polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp) approach. results: it was found that the single base substitution c to t at the coding region of the lsinct5 was not significantly associated with bladder cancer. genotype and allele frequencies were distributed evenly among cases and controls, but no tt genotype was observed. the history of smoking was significantly higher in bladder cancer patients compared to controls (p<0.001). conclusion: results showed that the lsinct5 polymorphism is not a key factor in the pathogenesis of bladder cancer. however, tobacco use is one of the strongest risk factors for bladder cancer.