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connecting the dots: a narrative exploration of breast cancer risks in sub-saharan african
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نویسنده
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chika ugwu emmanuel ,precious dike ujunwa ,king-david ahuchaogu
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منبع
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basic and clinical cancer research - 2025 - دوره : 17 - شماره : 2 - صفحه:547 -547
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چکیده
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Africa contribute significantly in the global burden of breast cancer. crucial efforts have been made to understand the landscape of breast cancer in sub-saharan africa (ssa). this article specifically examine the the existing evidence to better understand the risk factors that shape the epidemiology of breast cancer within the ssa region. this article sets off by discussing the epidemiology of breast cancer in ssa, with emphasis on how disparities occur in the region. the article explored the incidence rate across various countries in ssa. the article explored the various risk factors associated with breast cancer in ssa including genetic factors, relevant biomarkers, hormonal factors, reproductive factors, and some disparities in treatments amongst others. genetics mutations in brca1 and brca2 genes were discussed, buttressing how they contribute to the occurrence of breast cancer in the region. certain biomarkers were also identified as risk factors of breast cancer and deserving of mention is the kaiso biomarker. hormonal and reproductive factors such as age, breastfeeding time, family history, and body hormones such as estrogen and progesterone amongst others were identified as common risk factors of breast cancer in ssa. the poor treatment strategies and regimens in breast cancer care in ssa is also associated with breast cancer outcome, leading to an overall impact on the epidemiology of breast cancer in ssa. evidence-based recommendations were also made to improve breast cancer care in ssa. recommended techniques to addressing breast cancer care rely on genetic insights primarily aimed at informing a technologically-inclined future progress and research.
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کلیدواژه
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sub-saharan africa ,risk factors ,breast cancer ,genetics
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آدرس
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enugu state university of science and technology, faculty of pharmaceutical sciences, nigeria, university of port harcourt, faculty of pharmaceutical sciences, department of clinical pharmacy and management, nigeria. african community for systematic reviews and metaanalyses, nigeria, pharmacy council of nigeria(pcn) headquarters, nigeria. enugu state university of science and technology, faculty of pharmaceutical sciences, nigeria
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پست الکترونیکی
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davidahuchaogu@gmail.com
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Authors
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