survival of gej and gastric adenocarcinoma patients admitted at imam khomeini and aram oncology clinic and treated with preoperative eox chemotherapy

Objective: we aimed to investigate safety and efficacy of preoperative chemotherapy using eox regime in patients with locally advanced gastric and gej cancer who were admitted at imam-khomeini oncology clinic and aram clinic. method: we performed a mix-cohort study in 51 gastric cancer patients. in the beginning, we performed contrast thorax and abdominal ct scan or eco cardiograph to determine cancer staging. after that, each patient received 3-weeks eox regime in 6 cycle. after each three cycles follow-up ct scan was performed to assess any possible progression. response to the treatment, overall survival, and progression-free survival were the main outcomes that we evaluated in the current study. we used kaplan-meier approach and cox regression to address survival rate and its prognostic factors.results: overall, 72.5% percent were male and mean age of study participants was 57.6. complete response rate was observed in 11.1%, while 51.1% showed partial response. median of overall survival and progression-free survival was estimated 35.0 and 28.0 month, respectively. the 5-year overall survival was 74.2% and for pfs it was estimated at 57.7%.conclusion: preoperative chemotherapy using eox regime could increase survival rate among patients with gastric and gej cancer.