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dna oxidation-based analysis: a new approach to assessing the relationship between nutrition and cancer
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نویسنده
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karimi mehdi ,roudini kamran ,zendehdel abolfazl ,toorang fatemeh ,ebrahimpour-koujan soraiya
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منبع
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basic and clinical cancer research - 2021 - دوره : 13 - شماره : 4 - صفحه:258 -271
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چکیده
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Background: dna oxidation is one of the essential destructive effects of reactive oxygen species (ros) on the cell membrane macromolecules leading to the deformation of cellular dna. the most abundant oxidative dna product on which most studies have focused is re-oxidized dna, 8 oxo-deoxyguanosine (8-oxodg). this deformation of cellular dna is associated with various cancer initiation and progression. dna damage can be a cancer marker including 8-oxodg, thymidine glycol, 8-oxoadenine, etc. dna oxidation is affected by environmental and non-environmental factors. age, diet, and metabolism are at the heart of this process. this review study summarizes the types of cancer-related dna oxidation that serve as a cancer biomarker. also, we will look at the factors influencing their formation.
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کلیدواژه
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cancer ,dna ,oxidative damage ,mutation
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آدرس
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tehran university of medical sciences, school of nutritional sciences and dietetics, department of clinical nutrition, iran, tehran university of medical sciences, cancer institute, imam khomeini hospital complex, department of internal medicine, iran, tehran university of medical sciences, ziaeian hospital, geriatric department, family medicine department, iran, tehran university of medical sciences, school of nutritional sciences and dietetics, cancer research center of cancer institute of iran, department of community nutrition, iran, tehran university of medical sciences, school of nutritional sciences and dietetics, cancer research center of cancer institute of iran, autoimmune bullous diseases research center, razi hospital, department of clinical nutrition, iran
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پست الکترونیکی
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nutri.seam1@gmail.com
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Authors
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