the evaluation of rs11776042 polymorphism effect on colorectal cancer risk in the iranian population: a case-control study

Background: recently, it has been shown that, piwi-interacting rnas (pirnas) as a new class of non-coding rnas (ncrnas), play crucial roles in germline development and carcinogenesis. despite this, the study on the effects of pirnas polymorphism (pir-snp) on colorectal cancer (crc) risk is scarce. we evaluate the impact of rs11776042 in pirna 015551 on crc initiation and development in the iranian population for the first time. methods: the association of novel polymorphisms rs11776042 in pirna 015551 gene with crc risk using a case-control study on the iranian population was estimated. in this project 284 crc patients and 389 non-cancerous controls were evaluated by tetra primer-amplification refractory mutation system polymerase chain reaction (tp-arms- pcr assay). results: the genotypes frequency was 27%, 68% and 0.05% for c/c, c/t and t/t in controls and 31%, 65% and 0.04% in crc patients respectively. the frequency of the c allele was 63% in patients versus 61% in controls and, t allele frequency was 37% in patients versus 39% in controls. conclusion: no significant difference was found in genotype and allele frequencies between the cases and controls for rs11776042 polymorphism in pirna 015551 in our population.