Platelet-rich Plasma with Scaling and Root Planing: A Double-blind Split-mouth Randomized Study

Background and aims. along with conventional periodontal therapy, subginigval application of platelet-rich plasma (prp) may provide more effective improvements in clinical parameters due to the presence of multiple growth factors. the aim of this double-blind, split-mouth, randomized study was to evaluate the adjunctive use of prp with scaling and root planing (srp) in the treatment of chronic periodontitis. materials and methods. a total of 87 non-smokers suffering from moderate to severe chronic periodontitis were selected. parameters were probing pocket depth (ppd), clinical attachment level (cal), plaque index (pi) and modified bleeding index (mbi). after full-mouth srp the sites were randomly divided into experimental sites receiving subgingival application of autologous prp and controls treated with placebo gel. measurements were recorded at baseline, 3 months and 6 months. paired t-test was used to compare response to treatment between the two sites. results. statistically significant changes in parameters were seen in both groups from baseline to 6 months. inter-group comparison revealed significantly more clinical attachment gain for the experimental group (p>0.05). the mean cal gain was 2.40±0.4 mm for control sites and 2.68±0.5 mm for experimental sites. conclusion. this study supports the use of prp during nonsurgical debridement of periodontal pockets measured 6 months after srp.