is netrin-1 a reliable inflammatory marker for periodontitis?

Background. the current study tested netrin1- as a reliable inflammatory marker of periodontal disease. methods. gingival crevicular fluid (gcf) samples were taken at baseline from 30 systemically healthy individuals. fifteen subjects had stage ii grade a or b periodontitis, and 15 were periodontally and clinically healthy. whole-mouth periodontal parameters [probing depth (pd), clinical attachment loss (cal), plaque index (pi), and gingival index (gi)] were recorded. the gcf samples were re-collected, and clinical parameters were re-recorded after six weeks following full-mouth scaling and root planing (srp) in the periodontitis group. results. netrin1- gcf levels were significantly lower in periodontitis patients than periodontally healthy individuals at baseline with a significant increase in netrin1- gcf levels after srp (p<0.05). conclusion. netrin1- may have a significant role in the inflammatory process of chronic periodontitis; thus, it could be a promising anti-inflammatory marker in periodontal disease.