Clinical and radiographic diagnostic study of strontium ranelate and metal-substituted hydroxyapatite bone graft materials in diabetes mellitus with chronic

Background. the present study aimed to assess the clinical and radiographic effect of strontium ranelate and metal-substituted hydroxyapatite as bone graft materials on treating chronic periodontitis among diabetes mellitus patients. methods. a randomized split-mouth study was conducted on 20 sites in 10 controlled type ii diabetic patients suffering from chronic periodontitis. after phase i therapy, the sites were randomly allocated by a computer-generated table into two groups. group 1: a mucoperiosteal flap was elevated in 10 sites, followed by the placement of strontium ranelate mixed with gengigel. group 2: a mucoperiosteal flap was elevated in 10 opposite sites, followed by the placement of metal-substituted hydroxyapatite mixed with gengigel. clinical parameters were assessed at baseline and 3- and 6-month intervals. cone-beam computed tomography (cbct) was used at baseline and after six months to assess bone gain. results. the two treatment modalities resulted in a statistically significant reduction in clinical parameters at the 3- and 6-month intervals compared to the mean baseline value. intergroup comparison showed a significant reduction in probing pocket depth and clinical attachment loss in group 1 compared to group 2. comparison of the two sides by cbct showed a significant increase in the alveolar bone height in the sr group than the metal-substituted hydroxyapatite group. conclusion. clinical and radiographic results showed a significant improvement in the two groups and provided evidence that strontium ranelate is promising in treating periodontal diseases.