Investigation of the Association Between 584C/T Polymorphism of EL Gene and Risk of Premature Coronary Artery Disease in Fars Province

Introduction: endothelial lipase (el) is a protein from the triglyceride lipase family which plays an important role in high-density lipoprotein (hdl) metabolism. one of the most frequently studied variants is 584c/t which causes the amino acid threonine at codon 111 to convert to isoleucine. many studies have shown the association of this variant with hdl-c level and cad disease. methods: the population of this study consists of 140 patients (all males) with angiographically confirmed coronary artery disease (cad) and 80 controls. polymerase chain reaction and restriction fragment length polymorphism (pcr-rflp) was carried out for genotyping of lipg 584c/t. data were analyzed using spss. results: the results of the study indicated that the frequency of t allele was significantly lower among cad patients than among controls (0.27 vs 0.36, p = .004). however, no significant correlation was found between the 584c/t variant and serum hdl-c level. multivariate regression analysis confirmed that the t allele is significantly associated with cad disregarding the age, hypertension, hypercholesterolemia, diabetes and hdl-c (or = 0.494, 95% ci = 0.253- 0.968, p =.040). conclusion: it was concluded that the t allele was associated with protection from cad in fars province independent of hdl-c level.