Correlation of Serum Levels of Vitronectin, Malondialdehyde and Hs- CRP With Disease Severity in Coronary Artery Disease

Introduction: vitronectin (vn), malondialdehyde (mda) and high-sensitivity c-reactive rotein (hs-crp) are cooperative agents involved in the atherosclerosis process. the study was conducted to assess the correlation of vn, mda and hs-crp with the severity of coronary artery disease (cad). methods: parameters such as serum vn, mda and hs-crp were measured in 250 subjects including 200 patients with angiographically diagnosed cad (50 subjects with non-significant cad, 50 with single vessel disease, 50 with double vessel disease, and 50 with triple vessel disease) and 50 cad-free subjects as a control group. serum vn was measured with elisa; mda was measured based on reaction with thiobarbituric acid (tba); and hs-crp level was measured by a commercial kit by immunoturbidimetry. results: serum vn, mda and hs-crp were significantly higher in patient groups compared to control group (p < .05). the mean value of mda between 1 vessel and 3 vessel groups had significant difference (p = .01), also mean value of mda between 2 vessel and control group and normal group showed significant difference (p < .001). the difference of mda between 3 vessel and normal and 1 vessel and control group was significant (p < .001). conclusion: the association and correlation between vn, mda and hs-crp indicate their involvement in the atherosclerosis process that may lead to progression of cad. also, these findings suggested that serum levels of vn, mda and hs-crp can help as diagnostic and monitoring markers in cad patients and as markers of disease severity.