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   Effect of a Probiotic Preparation (VSL#3) on CardiovascularRisk Parameters in Critically-Ill Patients  
   
نویسنده Sanaie Sarvin ,Ebrahimi-Mameghani Mehrangiz ,Mahmoodpoor Ata ,Shadvar Kamran ,Golzari Samad EJ
منبع journal of cardiovascular and thoracic research - 2013 - دوره : 5 - شماره : 2 - صفحه:67 -70
چکیده    Introduction: cardiovascular disease (cvd) counts for a major portion of morbidity and mortality globally mostly accompanied by lipid abnormalities. being at increased risk of cardiac injury, critically ill patients suffer from various lipid disorders. lipid homeostasis has been efficiently restored by the introduction of probiotics. the aim of this trial was to determine the effect of probiotics on inflammation, antioxidant capacity and lipid peroxidation in critically ill patients. methods: forty patients admitted to the intensive care unit were randomized to receive placebo or probiotic for 7 days. serum levels of triglyceride (tg), total cholesterol, hdl-c, ldl-c and high- sensitivity c-reactive protein (hs-crp) were measured before initiation of the study and on the 7th day. results: there was a significant difference between two groups regarding the levels of tg, hdl and hs-crp at the end of the study (p= 0.043, <0.001 and 0.003, respectively); however, there was not a significant difference in total cholesterol and ldl-c levels. conclusion: administration of probiotics in critically ill patients reduced the levels of tg and hs-crp and increased hdl-c levels. however, no significant change was detected in levels of total cholesterol or ldl-c.
کلیدواژه Probiotic ,Critically Ill ,Lipid Profile ,Cardiovascular Disease
آدرس tabriz university of medical sciences, Faculty of Nutrition, Student Research Center, ایران, tabriz university of medical sciences, Faculty of Nutrition, Nutrition Research Center, ایران, tabriz university of medical sciences, Faculty of Medicine, Department of Anesthesiology and Intensive Care, ایران, tabriz university of medical sciences, Faculty of Medicine, Department of Anesthesiology and Intensive Care, ایران, tabriz university of medical sciences, Cardiovascular Research Center, Students’ Research Committee, ایران
 
     
   
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