polymorphism of rs599839 in the psrc1 gene is associated with coronary artery disease in an iranian population

Introduction: coronary artery disease (cad) is the leading health complication worldwide because of its high prevalence and mortality. the association between cad susceptibility and the rs599839 (c/t) polymorphism in the human proline and serine-rich coiled-coil (psrc1) was reported in a genome-wide association study. to validate this association, we performed this case-control study to genotype the 1p13.3 (rs599839) locus in a sample of the iranian population with cad (stenosis ≥ 70% in ≥ 1 coronary artery). methods: we performed an association analysis with pcr and sanger sequencing of rs599839 (c/t) polymorphism and cad risk in 280 cad patients and 287 healthy controls defined as a coronary calcium score of zero and no noncalcified plaques in coronary computed tomography angiography. spss, version 16.0, was applied for statistical analysis. results: the rs599839 (c/t) locus showed a significant association with cad (p value < 0.001). tt and ct genotypes were associated with cad (p value < 0.001). furthermore, the dominant status (tt + ct vs. cc) was associated with an increased risk of cad (or, 9.14; 95% ci, 3.77 to 22.15; and p value < 0.001). conclusion: the study findings indicate strong evidence for rs599839 (c/t) association with cad risk.