triglyceride-to-glucose index to detect a non-dipping circadian pattern in newly diagnosed hypertensive patients

Introduction: in this investigation, we aimed to explore the relationship between the triglyceride-glucose (tyg) index and the non-dipping blood pressure (bp) pattern in newly diagnosed hypertensive patients. methods: in this retrospective study, 216 consecutive newly diagnosed hypertensive patients who had undergone 24-hour ambulatory blood pressure (abpm) monitoring and had not received anti-hypertensive drugs were included. non-dipping status was evaluated by a 24-h abpm monitoring in all patients. we categorized the patients into two groups as; dippers (n = 104 cases) and non-dippers (n = 112 cases). the tyg index was derived from the fasting triglyceride and fasting glucose levels using the formula; ln[fasting triglyceride (mg/dl) × fasting glucose (mg/dl)/2]. results: non-dipper group had a higher tyg index than the dipper group. the tyg was an independent predictor of non-dipping bp in hypertensive individuals, according to multivariable analysis. the tyg index was negatively associated with a decrease in both systolic and diastolic bp during the nighttime. the ideal cutoff value of the tyg index in detecting non-dipping status was ≥ 9.01 with 74.1% sensitivity and 71.2% specificity. a roc comparison indicated that the area under the curve value of tyg index was superior to fasting triglyceride, fasting glucose, and homeostasis model assessment of ir (homa-ir) in detecting non-dipping bp. conclusion: the tyg index was an independent predictor of non-dipping status in newly diagnosed hypertensive patients who had undergone 24-hour abpm monitoring and had not received anti-hypertensive drugs. as a simple and easily obtained parameter, the tyg index can be used to detect such pattern among these patients.