association of rs4618210a>g variant in plcl2 gene with myocardial infarction: a case-control study in iran

Introduction: myocardial infarction (mi) is the leading cause of death all over the world. the pivotal roles of phospholipase c like 2 gene (plcl2) in calcium homeostasis and immune responses make this gene as a potential candidate for its role in mi pathogenesis. the present study was undertaken to investigate whether rs4618210a>g polymorphism in plcl2 gene contribute to mi etiology. methods: a hospitalbased casecontrol study with 600 subjects, including 300 mi patients and 300controls, was conducted. genotyping of plcl2 rs4618210 polymorphism was performed using amplification refractory mutation systempolymerase chain reaction (arms pcr) method. data were analyzed using logistic regression analysis. results: no significant association was found between the plcl2 rs4618210 alleles and mi risk.however, a significantly increased risk of mi was observed among carriers of the ag genotype (or= 1.91; 95% ci = 1.24 2.93; p = 0.003) compared with aa homozygote. in a dominant mode of inheritance for g allele (gg + ag vs. aa), the frequency of the carriers of at least one g allele was higher in cases compared to controls (or= 1.56; 95% ci: 1.03 – 2.36; p = 0.037). conclusion: our study provided further evidence that plcl2 gene polymorphism may serve as a prognostic marker for mi.