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   Decreasing serum homocysteine and hypocholesterolemic effects of Bovine lactoferrin in male rat fed with high-cholesterol diet  
   
نویسنده nozari samira ,fathi maroufi nazila ,nouri mohammad ,paytakhti oskouei mirhamid ,shiralizade javad ,yekani farshid ,mamipour mina ,faridvand yousef
منبع journal of cardiovascular and thoracic research - 2018 - دوره : 10 - شماره : 4 - صفحه:203 -208
چکیده    Introduction: lipid metabolism disorder or hyperlipidemia is known as a risk factor for cardiovascular disease, the increase in serum homocysteine and leptin are associated with atherosclerotic disease. the purpose of the present study was to examine the effects of bovine lactoferrin (blf) on serum homocysteine (hcy), apolipoproteina-i (apoa-i) and b (apob), leptin and lipid profile changes in high-cholesterol-diet (hcd) fed rats. methods: the healthy adult sprague-dawley (sd) male rats were randomly assigned into three experimental groups. each group consisted of eleven male rats including control group, hcd rats and hypercholesterolemic rats, which were treated with blf (hcd+blf). blf was given by gavage (200 mg/kg/d). after 4 weeks of feeding and overnight fasting, total blood samples were collected. results: the results showed the elevated level of hcy, leptin, total cholesterol, low density lipoprotein cholesterol (ldl-c), apob and decrease in apoa-i in non-treated hcd group compared to the control rats. administration of blf significantly ameliorated the hcy and leptin levels with decrease in ldl-c and total cholesterol in rats fed with a high-cholesterol diet. blf also tended to increase low serum concentration of apoa-i and high density lipoprotein cholesterol (hdl-c) in hcd rats. meanwhile, upon blf-treated rats, there was a significant decrease in apob in hcd group. conclusion: the findings indicated that blf can improve the alteration of serum hcy, leptin, apolipproteins and lipid changes in male rats fed with high-cholesterol diet. so, blf can counteract with hcd elicited hyper-homocysteinemia and hyper-leptinemia, suggesting it to have the useful therapeutic potential in patients with atherosclerosis and lipid disorder.
کلیدواژه Bovine Lactoferrin ,High-Cholesterol-Diet ,Homocysteinemia ,Leptin ,Apolipoprotein
آدرس tabriz university of medical sciences, stem cell research center, iran. tabriz university of medical sciences, student research committee, iran. tabriz university of medical sciences, stem cell and regenerative medicine institute (scarm), iran, tabriz university of medical sciences, faculty of medicine, department of biochemistry, clinical laboratories, iran, tabriz university of medical sciences, stem cell research center, iran. tabriz university of medical sciences, stem cell and regenerative medicine institute (scarm), iran, tabriz university of medical sciences, faculty of medicine, department of biochemistry and clinical laboratories, iran, payame noor university of mashhad, faculty of biology, department of biochemistry, iran, kharazmi university, faculty of biological sciences, department of animal biology, iran, tabriz university of medical sciences, stem cell research center, iran, tabriz university of medical sciences, stem cell research center, iran. tabriz university of medical sciences, stem cell and regenerative medicine institute (scarm), iran. urmia university of medical sciences, faculty of medicine, department of biochemistry, iran. tabriz university of medical sciences, cardiovascular research center, iran
پست الکترونیکی y.faridvand@yahoo.com
 
     
   
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