Role of plasma levels of CA-125 in predicting outcome of primary PCI after acute myocardial infarction in male patients

Introduction: cancer antigen 125 (ca-125) is a tumor marker of ovarian cancer, which has shown to be increased in different cardiovascular diseases. although the prognostic role of ca-125 in heart failure and coronary heart disease is well-established, there is little known about its role in acute myocardial infarction (ami). in this study we aimed to evaluate the serum levels of ca-125 in patients with ami and its prognostic role in evaluating the in-hospital outcome of ami. methods: we evaluated 120 male patients with ami and 120 male normal subjects. ca-125 levels were measured upon the patient’s admission to hospital. the in-hospital major adverse cardiac events (mace) and its predictors were also recorded for ami patients. results: ca-125 levels were significantly higher in ami patients compared to normal subjects (7.99±6.83 vs. 5.70±4.62, p = 0.003). we found significant positive correlations between ca- 125 levels with creatine kinase-mb (ckmb) (r=0.621, p < 0.001) and ctni (r=0.491, p < 0.001). the in-hospital mace was observed in 19 cases (15.8%). patients with mace had significantly higher value of ca-125, ckmb and ctni and lower lvef compared to patients without mace. ckmb (or=0.967, 95% ci [0.943-0.991], p = 0.007) and ca-125 levels (or=0.821, 95% ci [0.688-0.979], p = 0.02) were independent predictors of mace. conclusion: serum ca-125 levels are significantly higher in male patients with ami compared to normal subjects and have a significant role in predicting in-hospital mace after ami. in patients with higher ca-125 more aggressive treatment and close observation should be performed in order to reduce the possible adverse outcomes.