The Changes of Cardiac Troponin I and Creatine Kinase MB Isoenzyme after Percutaneous Transluminal Coronary Angioplasty

Background: percutaneous transluminal coronary angioplasty (ptca) with or without stenting is a well established technique for coronary revascularization. the injury to the myocardium during the technique was investigated by measuring serum levels for cardiac troponin i and activity of creatine kinase mb isoenzyme (ck-mb), the sensitive and relatively specific biomarkers of cardiac injury. in this study, to detect minor myocardial injury after ptca, we evaluated serum levels of ctni and ck-mb after ptca. methods: the serum levels of ctni and the activity of ck-mb were measured by standard methods in 100 patients undergoing elective ptca, before and 12-24h after the procedure. patients who had hepatic, renal and thyroid disease ; recent myocardial infarction; electrocardiographic changes, chest pain and myocardial infarction after intervention were excluded from our study. results: meaningful differences between the mean levels of ctni in the samples obtained before and after ptca; 0.67 ± 0.58 ng/ml vs 1.19 ±0.94 ng/ml (p= 0.000) and those of ck-mb activities; 22.89±8iu/l vs 26.38±13.39 (p=0.010) were noticed. stenting place had no effect on the measured parameters. relationships between history of hypertension, diabetes, hyperlipidemia, previous myocardial infarction, smoking and elevations of ctni and ck-mb levels weren’t statistically significant. the frequency of increased levels of ctni and ck-mb in women was significantly higher than men. conclusion: we concluded that minor cardiac injury following ptca may increase the serum level of ctni and serum activity of ck-mb. ctni is more sensitive than ck-mb in detecting of the injury and placing stent has no effect on the release of the parameters during the ptca.