Effects of Combined Training on the Levels of Obestatin, Ghrelin, and Insulin Resistance in Overweight Women

Background: the present quasi-experimental and field research was conducted to evaluate the effect of combined exercises on the levels of obestatin and ghrelin in overweight women. methods: the study subjects consisted of 34 overweight women with a mean±sd age of 30.29±4.66 years, a mean±sd height of 165.11±5.56 cm, a mean±sd weight of 74.64±7.33 kg, a mean±sd body mass index of 27.35±1.74 kg/m2, which were selected purposefully and randomly, and assigned to the experimental (n=17) and control (n=17) groups. at first, venous blood samples were taken from subjects after 12 h overnight fasting to measure the levels of ghrelin, obestatin, glucose, insulin, and insulin resistance. then, the participants of the experimental group participated in a combined exercise program, including warming up, aerobic training, resistance training, and cooling down. all these variables were re-measured after 12 weeks and the obtained data were analyzed. the paired t test was used for intra-group comparison and independent t test was performed for inter-group comparison. results: the findings of this study showed that body weight, bmi, waist circumference, glucose level, and ghrelin-obestatin ratio were significantly different between the experimental and the control groups (p≤0.05) after 8 weeks of combined exercise training, but differences in ghrelin, obestatin, insulin levels, and insulin resistance were not significant between the experimental and control groups (p≤0.05). conclusion: the combined exercise training, therefore, seems to be a suitable method for weight loss, body composition, waist circumference, glucose level, and ghrelin-obestatin ratio.