synthesis of yti@ag nanocomposite and investigation of its structural and antifungal properties

The aim of the current study is to describe the synthesis, characterization, and measurement of optical and antifungal properties of yb2tio5@ag nanocomposites (yti@ag) against three standard candida species including candida albicans (atcc 1023), candida krusei (atcc 6258), and candida tropicalis (atcc 750). yti@ag nanocomposites were synthesized through the sol-gel assistant ultrasonic method in an aqueous solution. the antifungal abilities were performed base on macrodilution method as recommended by the clinical and laboratory standards institute (clsi, document m27-a3). sem, xrd, edx, and ft-ir were applied to characterize structural and morphological characteristics of nanocomposites. in addition, several antifungal tests were performed to investigate the impact of yti@ag nanocomposites on the candida species. minimum inhibitory concentration (mic50) measurements of the yti@ag nps against c. albicans (atcc 1023), c. krusei (atcc 6258), and c. tropicalis (atcc 750) after 24 and 48 h were 4 and 32 µg/ml, respectively. mic50 results show that as-synthesized yti@ag nanocomposites are efficient as an alternative antibacterial/antifungal agent. the band gap of bare yb2tio5 and yti@ag nanocomposites is 3 and 2.85 ev, respectively. ag-doped yb2tio5 has advantage over naked yb2tio5 which enhances separation of electron–hole pairs which improves antifungal activity.