synthesis and biological evaluation of 3-(2,4-dichlorophenoxymethyl)-1-phenyl-1h-pyrazole derivatives as potential antitumor agents

Series of novel 3-(2,4-dichlorophenoxymethyl)-1-phenyl-1h-pyrazole derivatives with various substituents at positions 4 and 5 were synthesized. antitumor activity of all the synthesized compounds was evaluated by using srb assay on four cell lines: lung carcinoma (a549), human hepatocellular carcinoma (hepg2), colon carcinoma (hct116) and mammary gland breast cancer (mcf-7) cell lines. some of the synthesized compounds showed promising activity in comparison with doxorubicin against lung carcinoma cell lines. incorporating arylidene moiety at position-4 in pyrazole ring improved and displayed strong effect on the cytotoxic activity. compound 9c incorporating 4-chlorophenyl moiety was the most potent toward all tested cell lines.