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synthesis of some novel phenylfuro[3,2-d]pyrimidine glycosides derivatives with expected antimicrobial activity
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نویسنده
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ghoneim amira a. ,el-farargy ahmed f. ,elkanzi nadia a. a.
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منبع
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journal of the iranian chemical society - 2020 - دوره : 17 - شماره : 2 - صفحه:319 -325
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چکیده
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Reaction of ethyl 3-amino-5-phenylfuran-2-carboxylate 1 with benzoyl isothiocyanate gave 2,3-dihydro-6-phenyl-2-thioxofuro[3,2-d]pyrimidin-4-one. compound 3 was reacted with benzyl chloride to afford 2-(benzylthio)-6-phenylfuro[3,2-d]pyrimidin-4-one 4 and also reacted with bromoglucopyranosyl to give s-glycoside 5. the cyclization of ethyl 3-amino-5-phenylfuran-2-carboxylate 1 using thiourea, aniline, and carbon disulfide gave phenylfuro[3,2-d]pyrimidine derivatives. the pharmacological properties for the synthesized compounds were reported.
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کلیدواژه
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synthesis ,benzoyl isothiocyanate ,phenylfuro[2 ,3-d]pyrimidine ,glycosides ,antimicrobial activities
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آدرس
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jouf university, chemistry department, saudi arabia. zagazig university, faculty of science, chemistry department, egypt, zagazig university, faculty of science, chemistry department, egypt, jouf university, chemistry department, saudi arabia. aswan university, faculty of science, chemistry department, egypt
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Authors
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