one-pot synthesis and biological and catalytic applications of organometallic complexes involving oxazolines and (r)/(s)-a-phenylethylamine

The crystal structures of zinc complexes 1 and 3 were determined following synthesis via a one-pot method involving the reaction of 2-hydro-6-methyl-nicotinonitrile and 2-cyanopyridine with different l-amino alcohols mediated by 120–130 mol% zncl2. copper complex 4 and cobalt complex 5 were prepared by reacting (r)/(s)-a-phenylethylamine with dimethyl dichloride silane in the presence of 52 mol% cucl2 or 50 mol% cocl2 as the third components. crystalline compounds 1–5 were all characterized by elemental analysis, ir and nmr spectroscopies, and x-ray diffraction. then, complexes 1 and 3–5 were evaluated for cytotoxicity against the human tumor cell line smmc-7721 and were also used as catalysts in the nucleophilic addition reaction of trimethylsilonitrile with diphenylketimine. both complexes exhibited anticancer activity against the human tumor cell line smmc-7721 and showed enhanced catalytic effects.