>
Fa   |   Ar   |   En
   the correlation between ros generation and lpo process as the function of methylparaben concentrations during hemoglobin fructation  
   
نویسنده pishkari n. ,habibi-rezaei m. ,taghavi f. ,amanlou m. ,sheibani n. ,saso l. ,moosavi-movahedi a. a.
منبع journal of the iranian chemical society - 2020 - دوره : 17 - شماره : 5 - صفحه:1249 -1255
چکیده    In this study, we focused on the interference of methylparaben (mp), as the most commonly used paraben, on hemoglobin (hb) fructation, generating reactive oxygen species (ros) and resulting lipid peroxidation (lpo). we showed the enhancement of ros generation and heme degradation during hemoglobin fructation in the presence of mp using some biophysical techniques such as chemiluminescence and fluorescence spectroscopies, respectively. lipid peroxidation was observed using thiobarbituric acid reactive substances (tbars) assay, which correlated with ros production. also, the results showed that by increasing the levels of fructation, especially in diabetic-like groups, ros production was increased augmenting the intensity of lpo. this was accompanied by the elevation of malondialdehyde (mda) production. thus, mp has an adverse impact on hemoglobin by enhancing advance glycation end products (ages) and ros generation upon its fructation, which results in mda generation through enhanced lpo. this kind of research emphasises the importance of preservatives’ application revision especially methylparaben in various industries and the necessity of special attention to the consumption of these products by diabetic patients.
کلیدواژه fructation ,hemoglobin (hb) ,methylparaben (mp) ,reactive oxygen species (ros) ,lipid peroxidation (lpo)
آدرس university of tehran, institute of biochemistry and biophysics, iran, university of tehran, school of biology, college of science, center of excellence in nanobiomedicine, iran, tarbiat modares university, faculty of biological science, iran. university of tehran, iran, tehran university of medical sciences, faculty of drug design and development research center, department of medicinal chemistry, iran, university of wisconsin school of medicine and public health, department of ophthalmology and visual sciences, usa, sapienza university of rome, department of physiology and pharmacology “vittorio erspamer”, italy, university of tehran, institute of biochemistry and biophysics, iran
 
     
   
Authors
  
 
 

Copyright 2023
Islamic World Science Citation Center
All Rights Reserved