structural chemistry and anti-inflammatory activity of flexible/restricted phenyl dimers

Three phenyl dimer compounds, namely 3,3′-diformyldiphenoxyethane (c16h14o4) (1), 1-(4-[2-(4-acetyl-phenoxy)-ethoxy]-phenyl)-ethanone (c17h16n2o3) (2), 1-{4-[2-(4-acetyl-phenoxymethyl)-benzyloxy]-phenyl}-ethanone (c24h22o4) (3), were obtained and fully characterized, including their crystal structure determinations. the structural properties of two compounds 4, 4′-(ethylenedioxy)dibenzaldehyde) (c16h14o4) (tewari et al. acta cryst. e63:o1930, 2007) [1] (4) and 4-(2-phenoxy-ethoxy)-benzaldehyde (c15h14o3) (valgera et al. ccdc 710835, 2016) [2] (5) are discussed with the role of the substituent in crystal packing. in vivo, anti-inflammatory activities of all compounds were studied on wistar strain albino rats. all the compounds exhibited anti-inflammatory activity except 5. compounds 1, 2, 4 have shown moderate-to-intermediate effects on inhibitory properties. compound (3) with restricted rotation in the compound-like sc-558 drug was shown to possess good inhibitory properties at 180 min. in silico analysis was performed and compared with experimental in vivo results.