two novel nanostructured la(iii) coordination polymers were synthesized by sonochemical: crystal structures along with anticancer activity on human nasopharyngeal carcinoma cells

The preparation and the structural characterization of two la(iii)-based coordination polymers was described in this study, in which {[la(h2o)(btctb)]·2h2o}n (1, h3btctb = 3,3′,3′′-[1,3,5‐benzenetriyltris(carbonyl amino)] three benzoic acid) and [(la2(tatab)2)·4dmf·4h2o]n (2, h3tatab = 4,4,4″s-triazine-1,3,5-triethyl-m-aminobenzoic acid) were prepared by means of two flexible tricarboxylic acid ligands with different joints and functional backbones. moreover, a sonochemical synthesis way has been carried out to produce the nanostructures of complexes 1 and 2. in addition, their anticancer activity was evaluated on nasopharyngeal carcinoma cells. firstly, cell counting kit-8 test kit was used to test the cancer cells proliferation after treated with nano 1 or 2. then, the annexin v-fitc/pi test was performed and the percentage of the apoptotic cancer cells was determined after nano 1 and 2 treatment. next, the ros accumulation after nano 1 and 2 treatment was detected by dcfh-da detection kit. finally, the expression level of fhit in nasopharyngeal carcinoma cells treated with nano 1 and 2 was evaluated via western blot.