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   an efficient one-pot synthesis of highly substituted [1,8]naphthyridin-1-phenyl-1-ethanone derivatives via a four-component reaction  
   
نویسنده alizadeh abdolali ,roosta atefeh ,halvagar mohammad reza
منبع journal of the iranian chemical society - 2017 - دوره : 14 - شماره : 10 - صفحه:2157 -2165
چکیده    An operationally simple one-pot protocol for the synthesis of highly substituted [1,8]naphthyridin-1-phenyl-1-ethanones dealing with 2-chloroquinoline-3-carbaldehyde and 1-phenyl-2-(1,1,1-triphenyl-λ 5-phosphanylidene)ethan-1-one, 1,1-bis(methylthio)-2-nitroethylene or ketene n,s-acetals, and aromatic/aliphatic amine or diamines under mild and catalyst-free conditions in excellent yields is described. the structures of products were corroborated spectroscopically (ir, 1h- and 13c-nmr, and ei-ms) and by x-ray analysis. an efficient, useful and general procedure for the synthesis of [1,8]naphthyridin-1-phenyl-1-ethanones via a one-pot four-component reaction of 2-chloroquinoline-3-carbaldehyde and 1-phenyl-2-(1,1,1-triphenyl-λ 5-phosphanylidene)ethan-1-one, 1,1-bis(methylthio)-2-nitroethylene or ketene n,s-acetals, and aromatic/aliphatic amine or diamines under mild and catalyst-free conditions in excellent yields is described. the major advantages of this protocol are high yields, mild and catalyst-free conditions, short reaction times, and application of green solvent.
کلیدواژه 2-chloroquinoline-3-carbaldehyde ,1-phenyl-2-(1 ,1-triphenyl-λ 5-phosphanylidene)ethan-1-one ,1-bis(methylthio)-2-nitroethylene ,ketene n ,s-acetals ,aliphatic amine or diamines ,multicomponent reaction
آدرس tarbiat modares university, department of chemistry, iran, tarbiat modares university, department of chemistry, iran, chemistry and chemical engineering research center of iran, department of inorganic chemistry, iran
 
     
   
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