voltammetric behavior of acebutolol on pencil graphite electrode: highly sensitive determination in real samples by square-wave anodic stripping voltammetry

In this work, an electrochemical investigation of acebutolol (ace), a beta-blocker drug, was carried out in alkaline medium using pencil graphite (pg) electrode. in cyclic voltammetry, the compound displayed a reversible and adsorption-controlled oxidation peak. by using square-wave anodic stripping voltammetry, the oxidation peak current observed at +0.78 v showed a linear relationship with concentration at 0.4–7 nm interval in britton–robinson buffer (ph 10.0) and a detection limit of 0.09 nm. the relative standard deviation of 4.72% for the concentration level of 2.0 nm (n = 11) was also calculated. the pg electrode that is used for the first time in this method was successfully applied to determine the ace in pharmaceutical formulations and urine.