[bmim]5[pniw11o39]·3h2o an organic–inorganic hybrid as catalyst for one-pot pseudo-five-component synthesis of tetrazolyldiazepines

In this research, two heterogeneous organic–inorganic hybrid catalysts, [bmim]3[pw12o40]·3h2o and [bmim]5[pniw11o39]·3h2o, have been prepared. the catalysts were fully characterized by several techniques such as elemental analyses, fourier transform infrared spectroscopy, thermo-gravimetric analysis, scanning electron microscope and energy-dispersive x-ray analysis. next, the hybrid catalysts have been used for the synthesis of functionalized diazepines containing tetrazole ring. tetrazolyl-1h-spiro[benzo[b]cyclopenta[e][1,4] diazepines products were obtained in excellent yields and mild experimental conditions using [bmim]5[pniw11o39]·3h2o as catalyst. this process was carried out via a one-pot, pseudo-five-component condensation reaction by means of a 1,2-diamine, isocyanide, tmsn3 and two molecules of a linear or cyclic ketone in methanol, at ambient temperature.