|
|
|
|
a novel and facile route for the synthesis of medetomidine as the α2-adrenoceptor agonist
|
|
|
|
|
|
|
|
نویسنده
|
kaboudin babak ,haghighat hamideh ,aieni samira ,behrouzi leila ,kazemi foad ,kato jun-ya ,aoyama hiroshi ,yokomatsu tsutomu
|
|
منبع
|
journal of the iranian chemical society - 2017 - دوره : 14 - شماره : 8 - صفحه:1735 -1739
|
|
چکیده
|
We report here a novel and facile method for the synthesis of (±)-4(5)-[1-(2,3-dimethylphenyl)ethyl]-1h-imidazole (medetomidine) in a good yield in five steps. the method involves wittig olefination of the phenylimidazolylketones, followed by a hydrogenation. we demonstrate that the wittig alkenylation reaction provides a convenient step for the synthesis of medetomidine without requiring methylation and dehydration steps, which are problematic processes in the previous methods. novel route for the synthesis of medetomidine.
|
|
کلیدواژه
|
imidazole ,medetomidine ,wittig reaction ,α2-adrenoceptor agonist ,methanone
|
|
آدرس
|
institute for advanced studies in basic sciences(iasbs), department of chemistry, iran, institute for advanced studies in basic sciences(iasbs), department of chemistry, iran, institute for advanced studies in basic sciences(iasbs), department of chemistry, iran, institute for advanced studies in basic sciences(iasbs), department of chemistry, iran, institute for advanced studies in basic sciences(iasbs), department of chemistry, iran, tokyo university of pharmacy and life sciences, school of pharmacy, japan, tokyo university of pharmacy and life sciences, school of pharmacy, japan, tokyo university of pharmacy and life sciences, school of pharmacy, japan
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|