a novel thermo-sensitive nanogel composing of poly(n-isopropylacrylamide) grafted onto alginate-modified graphene oxide for hydrophilic anticancer drug delivery

Nanogels have been demonstrated to be desirable for hydrophilic anticancer drug delivery. this study presents a novel nanogel consisting of sodium alginate-modified graphene oxide (sa-go) and n-isopropylacrylamide (nipam) for sustained delivery of doxorubicin (dox) drug. the pnipam/sa-go nanogel was studied by various techniques including scanning electron microscopy, atomic force microscopy, dynamic light scattering, fourier transform infrared spectroscopy, and thermo-gravimetric analysis. subsequently, the thermo-responsive behavior of the pnipam/sa-go nanogel was investigated by uv–vis spectroscopy. dox was successfully loaded into the pnipam/sa-go nanogel in order to study entrapment efficiency and drug release behavior. moreover, biocompatibility of the dox-loaded pnipam/sa-go nanogel was examined against hella cells and was compared with free pnipam/sa-go nanogel and dox. this work offers that the nanogels could be developed further as an effective bioactive molecule delivery system.