synthesis of bis-coumarins over acetic acid functionalized poly(4-vinylpyridinum) bromide (apvpb) as a green and efficient catalyst under solvent-free conditions and their biological activity

In this work, acetic acid functionalized poly(4-vinylpyridinum) bromide as a green and reusable catalyst was successfully tested on the synthesis of various bis-coumarins under solvent-free conditions. in addition, antioxidant and anti-inflammatory activities of the synthesized bis-coumarins were in vitro screened by 2,2-diphenyl-1-picrylhydrazyl (dpph) free radical scavenging and formalin-induced edema model system, respectively. antifungal activity was also evaluated against fusarium oxysporum. results showed that the synthesized bis-coumarins studied possess strong antioxidant (ic50; 0.149 ± 0.005 to 1.348 ± 0.006 mg/ml) and anti-inflammatory activities in comparison with ascorbic acid and diclofenac as positive controls, respectively. also, the compounds showed good inhibition activity against fusarium oxysporum (58 ± 1.4 to 100 ± 0.0%). for their biological activities, the synthesized bis-coumarins be suggested to apply as biological agents for special use in future.