synthesis of a polymer-capped palladium nanoparticles and its application as a reusable catalyst in oxidative coupling reaction of α-hydroxyketones and 1,2-diamines for preparation of pyrazines and quinoxalines

A novel method for the synthesis of pyrazines and quinoxalines has been developed using α-hydroxyketones and 1,2-diamines in the presence of cross-linked poly(4-vinylpyridine)-stabilized pd(0) nanoparticles, [p4-vp]-pdnps. the catalyst was easily prepared and characterized using various techniques such as ft-ir and uv–vis spectroscopy, aas, tem, fesem, edx analysis and xrd. the results confirm a good dispersion of palladium nanoparticles on the polymer support. the catalyst displayed good catalytic activity when applied to the synthesis of quinoxalines via condensation of α-hydroxyketones with 1,2-diamines. a few pyrazine derivatives and various quinoxalines are prepared via coupling reaction of α-hydroxyketones and 1,2-diamines in high–excellent yields (81–99%) with short reaction times. the quinoxalines products were characterized by ft-ir, 1h and 13c nmr spectroscopy, and the physical properties were compared to the literature values of known compounds. the advantages of the present method over conventional classical methods are rapid and very simple work-up, and the catalyst is reusable many times without a significant loss in its activity.