aluminized polyborate: a novel catalyst for the multicomponent solvent-free synthesis of alkyl 1,2,6-trisubstituted-4-[(hetero)arylamino]-1,2,5,6-tetrahydropyridine-3-carboxylates

An efficient and simple method for the one-pot three-component synthesis of alkyl 1,2,6-trisubstituted-4-[(hetero)arylamino]-1,2,5,6-tetrahydropyridine-3-carboxylates was developed using aromatic aldehyde, amine and β-ketoesters catalyzed by aluminized polyborate, an efficient reusable catalyst under solvent-free condition. aluminized polyborate has advantageous of cost, ecologically benefits, accessible preparation and recyclability up to five cycles along with high product yield and simplicity.